Identification of new gonadotrophin-releasing hormone partial agonists

Comparing gonadotrophin-releasing hormone agonists or gonadotrophin-releasing hormone antagonists in poor responder in IVF

Objective: The use of GnRH antagonist versus GnRH agonist in poor responder for patient undergoing ovarian hyperstimulation and in vitro-fertilization was compared. Materials and Methods: In this study, 23 patients underwent ovarian hyperstimulation with recombinant FSH followed by the use of GnRH antagonist (Cetrorelix) 0.25mg during the late Follicular Phase. These patients were compared to 2...

Gonadotrophin-releasing hormone.

Analogues of gonadotrophin releasing hormone.

Rapid nongenomic effects of oestradiol on gonadotrophin-releasing hormone neurones.

That oestradiol can have both negative- and positive-feedback actions upon the release of gonadotrophin-releasing hormone (GnRH) has been understood for decades. The vast majority of studies have investigated the effects of in vivo oestrogen administration. In the past decade, evidence has accumulated in many neuronal and non-neuronal systems indicating that, in addition to traditional genomic ...

Two types of burst firing in gonadotrophin-releasing hormone neurones.

Gonadotrophin-releasing hormone (GnRH) neurones fire spontaneous bursts of action potentials, although little is understood about the underlying mechanisms. In the present study, we report evidence for two types of bursting/oscillation driven by different mechanisms. Properties of these different types are clarified using mathematical modelling and a recently developed active-phase/silent-phase...